Resolved networks from a single time series.

Using simulated annealing the (A) 1∶1, (B) SMS and (D) uniform networks are resolved to up to four consecutive switches, although the complex lattice network (C) is less well described. The starter genes, which were assumed to be clonally transcribed at generation 0, are highlighted in red. The simulated time courses (right column) show a very good agreement between the target data and the transcription data resulting from the determined network.