Residues involved in binding mapped onto HEPN crystal structure.

<p>Residues that produced chemical shift changes during the NMR titrations with DMSO (A), AN670 (B), AK968 (C) and AN652 (D) were mapped onto the HEPN crystal structure. In each structure, DMSO-binding residues are labeled in <i>blue</i> and additional residues binding to the hit candidates are labeled in <i>red</i>.</p>