Figure_2.tif (600.76 kB)
Reduced Th2 cytokine production after in vitro restimulation of thoracic cavity cells of acute, but not chronically L. sigmodontis infected ST2-ko mice.
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posted on 2014-03-24, 03:13 authored by Jesuthas Ajendra, Sabine Specht, Anna-Lena Neumann, Fabian Gondorf, David Schmidt, Katrin Gentil, Wolfgang H. Hoffmann, Mark J. Taylor, Achim Hoerauf, Marc P. HübnerIsolated cells from the thoracic cavity of individual L. sigmodontis infected wild type (WT) or ST2-ko mice were cultured in vitro with either L. sigmodontis antigen (LsAg, left panel) or ConA (right panel). IL-4 (A,B), IL-5 (C,D), IL-10 (E,F), IFNγ (G,H), IL-33 (I,J) and IL-25 (K,L) within the culture supernatants were measured on days 35, 60 or 100 post infection. Data is representative for two independent experiments with at least 5 mice per group. Differences were tested for statistical significance by Mann-Whitney-U-test, *p<0.05, **p<0.01.
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immunologyImmune responseimmunityImmunity to infectionsorganismsanimalsvertebratesmammalsrodentsratsInfectious diseasesParasitic diseasesHelminth infectionsfilariasisLymphatic filariasisonchocerciasisTropical diseasesneglected tropical diseasesModel organismsAnimal modelsMouse modelsth2cytokinevitrorestimulationthoraciccavitycellschronicallyinfectedst2-ko
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