Reconstructed spliceosome sub-network of M. musculus.

(A) The reconstructed spliceosome sub-network consists of including 99 proteins and 1,014 predicted PPIs, including 655 PPIs from only generalized interolog mapping methods (grey edges); 197 PPIs from only our method with S ≥ 2.3 (orange edges); and 162 PPIs from the overlap between generalized interolog mapping and our method (green edges). The sub-network consists of five structural complexes (i.e., U1-snRNP, U2-snRNP, U4/U6.U5 tri-snRNP, Prp19/CDC5L complex and 35S U5-snRNP) recorded in KEGG. Furthermore, three modules are recorded in the CORUM: Sm core, CDC5L core, and LSm2-8 complexes. The blue nodes are essential genes collected from the Mouse Genome Informatics database. (B) The two Sm core complexes are based on generalized interolog mapping (five PPIs) and our method with S ≥ 2.3 (14 PPIs). (C) The CDC5L core complex with five proteins and six PPIs based on our method (score S ≥ 2.3).