Protection of mice from lung viremia.

Groups of CD1 mice were immunized twice with five-fold serial dilutions of pandemic H1N1 (H1N1 A/California/7/2009) whole virus vaccine, before being challenged intranasally with 105 TCID50. Lungs were harvested at day three after challenge, and virus titers determined as described (Methods). Lack of detection of virus in lungs was considered indicative of protection.



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