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Pronephric Obstruction Blocks Proximal Cell Migration

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posted on 2009-01-06, 00:36 authored by Aleksandr Vasilyev, Yan Liu, Sudha Mudumana, Steve Mangos, Pui-Ying Lam, Arindam Majumdar, Jinhua Zhao, Kar-Lai Poon, Igor Kondrychyn, Vladimir Korzh, Iain A Drummond

(A) Unilateral obstruction, NaK ATPase:GFP, the obstructed side is shown below the control side.

(B) Complete obstruction, ET11–9 GFP transgenic. The epithelial cells move circumferentially. Frame intervals in (A, B) are 2.5 h, scale bar: 70 μm.

(C) Rates of migration in various conditions, from left to right: unilateral obstruction, unobstructed side (white bar); unilateral obstruction, obstructed side (striped bar); complete obstruction, rate of anterior migration (black bar); complete obstruction, rate of circumferential movement (mesh bar). Each bar represents average over a number of cells within a single experiment.

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