Predictions for Gp120 plotted on the protein structure including bound antibody.

Each residue in the structure is colored from blue to red according to its DiscoTope-2.0 score. Blue indicates low scores (predicted to be non-epitope residue) and red indicates high scores (predicted to be epitope residue). Yellow indicates possible glycosylation sites retrieved from UNIPROT accession number P04578 (www.uniprot.org). a) Gp120 surface representation and antibody cartoon representation. b) Gp120 and antibody cartoon representation. Note, the red alpha-1 helix, which is normally buried in the inner domain of Gp120 involved in Gp41∶Gp120 complex formation, is exposed in the crystal structure.