Predictions filtered by conservation, accessibility, or both are more downregulated than non-filtered predictions.
Mean log2 fold changes in protein expression are shown for the targets of five highly conserved miRNAs, predicted using PACCMIT with different filters. The log2 fold changes are taken from Selbach et al. . Statistical significance is given by the one-sided Wilcoxon rank sum test (*P≤0.05, **P≤0.01, ***P≤0.001). P-values>0.05 are not indicated. Error bars indicate standard errors of the mean.