Predicted protein conformational changes.
Locations of the observed mutations within the structures of EBOV proteins: a) GP truncations – occur right after a disordered region in the crystal structure. The truncation also removes the ends of the trimer (in red). b) GP1,2 – residue E47 (vdW spheres) is near the top of the trimer and, in the X-ray crystal structure (3CSY), makes no interactions with other side chains. c) VP24 – residue K163 forms a tight salt-bridge with D104 on another helix near an undetermined loop in the X-ray structure.