Plasma apoE and lipid levels.

Representative Western blot (A) and quantification (B; n = 3) of the band intensity of plasma apoE from wild type (WT), Apoe−/− (E−/−), Apoeh/h and Apoeh/hLysM-Cre mice either fed a chow diet or a high cholesterol diet (HCD); mean±sem, two-way ANOVA Bonferonni post-tests, **p<0.01 and t-test #p<0.05. Plasma cholesterol (n = 7; mean±sem, one-way ANOVA post-test, ***p<0.001; C) and lipoprotein cholesterol distribution (pooled of 7 mice; D) are shown; inset: Western blot of apoB and quantification (n = 3); mean±sem, two-way ANOVA Bonferonni post-tests, **p<0.01, ***p<0.001. Representative Western Blot of apoE distribution in lipoprotein fractions (E).