Patient and healthy control characteristics at baseline.

a

Median number of years from first symptoms of MS to inclusion.

b

Treatment within 4 months before baseline CSF sample.

c

Three patients were treated with high-dose corticosteroids, in addition to interferon-β (2 patients) and glatiramer acetate (1 patient) respectively, due to relapses.

***

p<0.0005 compared with MS patients using independent samples t-test.

Abbreviations: RRMS = relapsing-remitting MS; PRMS = progressive MS with superimposed relapses; HC = healthy controls, EDSS = Expanded Disability Status Scale; CSF = cerebrospinal fluid, NA = not applicable.

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