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PS2 protein is increased in microglia activated by IFNγ.

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posted on 2010-12-29, 00:05 authored by Suman Jayadev, Amanda Case, Alison J. Eastman, Huy Nguyen, Julia Pollak, Jesse C. Wiley, Thomas Möller, Richard S. Morrison, Gwenn A. Garden

A) Western blot analysis demonstrating the PS2 C-terminus migrating at ∼20 kDa. Twenty-four hour stimulation with 10 u/ml IFNγ induces increased levels of PS2 expression in lysates prepared from primary microglia, while 100 ng/ml LPS does not induce PS2 expression. B) Quantitative densitometry on Western blots of lysates from 4 independent cultures shows significantly increased induction of PS2 by IFNγ. Data represent the mean ± SEM of 4 independent experiments (*p<0.05; Student's t-test). C) Twenty-four hour stimulation of primary microglia with IFNγ results in significantly increased PS2 mRNA. Data represent the mean ± SEM of 3 independent experiments (** p<0.01 by Student's t-test).

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