Fig_7.tif (842.28 kB)
Overexpression of miR-29a increased histone H3 at lysine 9 (H3K9Ac) and decreased Smad3 expression in HSCs.
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posted on 2015-08-25, 03:07 authored by Ying-Hsien Huang, Mao-Meng Tiao, Li-Tung Huang, Jiin-Haur Chuang, Kuang-Che Kuo, Ya-Ling Yang, Feng-Sheng WangA miR-29a mimic and HDAC4 RNAi significantly increased H3K9Ac and decreased both Smad3 and p-Smad3 expression in HSCs of WT mice. Data are expressed as the mean ± SE of four independent experiments. *indicates a p < 0.05 between the groups.
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HDAC 4Histone Deacetylases 4 BackgroundRecent studiesHDAC 4 functionprofibrogenic gene expressionhistone deacetylases 4migration assays.ResultsAfter BDLHSC migrationcholestatic liver fibrosisglial fibrillary acidic protein expressionprofibrogenic phenotypeantisense inhibitormirHSC activationHepatic Stellate CellsHSC proliferation.ConclusionsOur resultsActivated Hepatic Stellate Cells Modulates
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