Overexpression of miR-29a increased histone H3 at lysine 9 (H3K9Ac) and decreased Smad3 expression in HSCs.

A miR-29a mimic and HDAC4 RNAi significantly increased H3K9Ac and decreased both Smad3 and p-Smad3 expression in HSCs of WT mice. Data are expressed as the mean ± SE of four independent experiments. *indicates a p < 0.05 between the groups.