Overexpression of miR-29a decreased GFAP, a marker of HSC, and increased expression in the acute response to injury and immunoreactivity in cholestasis.

<p>There was significantly higher expression of GFAP (green) in tissues from the BDL group than in tissues from the sham-operated group in WT mice. Moreover, miR-29a overexpression significantly downregulated GFAP protein expression in miR-29aTg mice with cholestasis compared with the WT littermates. Data are expressed as the mean ± SE of six samples per group. *indicates a p < 0.05 between the groups.</p>