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OA and derivatives evoke a vasodilation in aorta and mesenteric arteries from Wistar rats.

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posted on 2016-01-28, 12:39 authored by Hlengiwe P. Madlala, Thomas Metzinger, Fanie R. van Heerden, Cephas T. Musabayane, Kanigula Mubagwa, Chantal Dessy

Original tracing [A] for Br-OA in mesenteric arteries precontracted with KCl. Concentration-response curves for solvent, OA, Me-OA, and Br-OA in endothelium-intact mesenteric arteries [B, C] or aortic rings [C, D] isolated from Wistar rats, pre-contracted with sub-maximal concentration of PE (5 μM) [A, C] and KCl (50 mM) [B, D]. The values shown are means ± SEM (n = 7). * p ˂ 0.001 vs control, # vs Br-OA.

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