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Neuronal interactions involving cocaine- and amphetamine-regulated transcript (CART)-containing kisspeptin (KP), neurokinin B (NKB) and substance P (SP) neurons in the infundibular nucleus (Inf).

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posted on 2014-08-01, 03:41 authored by Katalin Skrapits, Beáta Á. Borsay, László Herczeg, Philippe Ciofi, Stephen R. Bloom, Mohammad A. Ghatei, Waljit S. Dhillo, Zsolt Liposits, Erik Hrabovszky

Neuropeptides exhibit variable colocalization patterns in neuronal cell bodies and fibers of the Inf (see color-coded captions). Single-, double- and triple-labeled peptidergic axons establish appositions onto other peptidergic neurons. Such appositions often involve CART-IR neuronal elements. The CART/KP/NKB triple-labeled cell body in A and B receives an axo-somatic afferent contact from a single-labeled CART-IR axon (green arrow in B). The CART/KP double-labeled cell body in C and D receives an afferent contact from a KP/NKB double-IR axon (purple arrows in D). A CART/SP double-IR neuron in E is innervated by KP-IR (red arrows) and KP/SP double-IR (purple arrow) axons. The dendrite of a GnRH neuron (brown pseudocolor) in F receives innervation from a CART/KP/NKB-IR triple-phenotype axon (white arrow). Scale bars = 20 µm in A, C, 12 µm in E and 10 µm in B, D and F.

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