Nasal sensitization of mice with ragweed pollen mimics the symptoms of human local allergic rhinitis.

Mice were nasally sensitized with ragweed (RW) pollen. (A) Experimental schema. (B) Numbers of sneezes. (C–F) Mice were nasally administered RW pollen on indicated consecutive days. (C) Serum immunoglobulin levels. Production of cytokines in cLN cells (D) and nasal CD4+ T cells (E). (F) Presence of eosinophils in nasal mucosa. Data representative of three independent experiments (means and SEMs of (B) five mice and (C–F) three mice). *P<0.05, **P<0.01, ***P<0.001. N.D. not detected.