Figure_4.tif (144.42 kB)
Mutation counts and rates in viral clones.
figure
posted on 2010-05-06, 00:26 authored by Lance D. Eckerle, Michelle M. Becker, Rebecca A. Halpin, Kelvin Li, Eli Venter, Xiaotao Lu, Sana Scherbakova, Rachel L. Graham, Ralph S. Baric, Timothy B. Stockwell, David J. Spiro, Mark R. DenisonComplete genome sequences were determined for 10 SARS-WT and 10 S-ExoN1 P3 viral clones. Numbers of total (A) or unique (B) non-engineered nucleotide substitutions identified in SARS-WT and S-ExoN1 genomes are indicated. Each circle represents the mutation count value from a single genome sequence and lines indicate mean mutation counts. Rates of accumulation of unique substitutions per replication cycle on a per nucleotide (C) or per genome (D) basis. Mean values are plotted and error bars indicate standard deviations. *, P<0.0005; Wilcoxon rank-sum test.
