Multivariate analysis for disease-specific death.

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95% CI = 95% confidence interval;

*61 patients had unknown values for LDH and were excluded; no confounding and no significant interaction was detected.

**122 patients had unknown values for LDH and/or S100 and were excluded; the model was adjusted for the confounding effects of M Stage IV; no significant interaction was detected.

***127 patients had unknown values for LDH and/or S100 and/or could not be aligned to one of the 4 treatment categories and were excluded; the model was adjusted for the confounding effects of the M category; no significant interaction was detected.

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