Multiple sequence alignment of the three isoforms of hVDAC.

Residues are numbered according to hVDAC1 and hVDAC3 sequence (283 AA), thus, the first 11 N-terminal residues of hVDAC2 (293 AA) are not numbered in the figure and are referred to as 1′-11′ throughout the paper. Acidic residues are colored in red, basic ones in blue. Histidines have been distinguished from the latter and colored (green). The yellow arrows show the 19 β-strands forming the barrel. (Sequence alignment was obtained through ClustalW2 at http://www.ebi.ac.uk/Tools/msa/clustalw2/).