Mortality and virus replication after intranasal NSV infection.

(A) 6-9 week-old WTB6 (N = 11), GKO (N = 24) and GRKO (N = 23) mice were infected intranasally with 105 pfu NSV and followed daily for mortality which was similar. P = 0.47. At 3, 5, and 7 d after infection, brains (B), cervical (C) and lumbar (D) spinal cords from 3 WTB6, GKO or GRKO mice were assayed for infectious virus by plaque formation on BHK cells. LOD = limit of detection. * P < 0.02; t test.

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