Model for Gene Dosage Effect of PcG Genes on Stem Cells and Cancer

2013-02-21T10:34:31Z (GMT) by Martin Sauvageau Guy Sauvageau

Adequate PcG gene levels, such as in wild-type cells (+/+), seem to be crucial for normal stem cell functions. Either overexpression (+++) or partial loss of function (+/−) of PcG genes leads to an increase in tumor development. In turn, complete ablation (−/−) is detrimental and leads to impairment or loss of stem cells.



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