Figure_6.tif (295.39 kB)
Lovastatin treatment reduces pro-inflammatory cytokine levels in the brains of animals with CM.
figure
posted on 2012-12-27, 02:16 authored by Patricia A. Reis, Vanessa Estato, Tathiany I. da Silva, Joana C. d'Avila, Luciana D. Siqueira, Edson F. Assis, Patricia T. Bozza, Fernando A. Bozza, Eduardo V. Tibiriça, Guy A. Zimmerman, Hugo C. Castro-Faria-NetoIL-1β (A), TNF-α (B), IL-12 (C) levels were determined by ELISA in brains of mice 6 days after infection with PbA (106 PRBC, n = 6–10/group). Lovastatin (10–40 mg/kg) was orally administered on day 6 post-infection together with chloroquine (25 mg/kg). *p<0.05 or less (Tukey's Multiple Comparison test) in relation to non-infected group and #p<0.05 or less in relation to PbA-infected group (Mann-Withney U Test).
