Loss of functional integrity of RVLM precedes cardiovascular depression.

(a) Temporal changes in MSAP, HR or power density of LF component of SAP spectrum in rats that received consecutive microinjections (at arrows) of a lethal dose of Mev (280 nmol) bilaterally into the RVLM or sites immediately adjacent to the RVLM (non-RVLM). (b) Re-drawn of (a) between the 9th [dotted line in (a)] and 16th min on an expanded scale showing temporal changes in LF power. Values are mean±SEM of 5–7 animals per experimental group. *p<0.05 versus artificial cerebrospinal fluid (aCSF) group or non-RVLM group at corresponding time-points in the post hoc Scheffé multiple-range analysis following two-way ANOVA.