Local sensitivity analysis at the steady states of four GAL mRNAs with respect to all model parameters.

The heat map denotes the average absolute value of the normalized sensitivity coefficients of four GAL mRNA across 1000 minutes. The parameters , , , , , , , , , , and are smaller than 0.25, while the others are larger than 1. This implies the reaction terms associated with insensitive parameters can be omitted no matter which mRNA is chosen as the control target. One can conclude not only that the control model targeting GAL1 mRNA need not include the terms associated with the above parameters, but also that control strategies targeting all four GAL mRNAs can suppress the same terms. The reduced model can thus be used for the control design targeting any of the four GAL mRNAs.



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