LPS-induced rapid reduction of BCL6 levels does not occur in MyD88^−/− TRIF^−/− mice.

WT or MyD88^−/− TRIF^−/− mice were i.p. injected with LPS. (A) Representative FACS plots (n = 4) showing CD11c and I-A/E expression on splenic cells in 0 h or 24 h post-LPS injected mice. (B) and (C) The MFI±SEM (n = 4) of CD11c (B) and CD86 (C) in gated splenic CD11c^int I-A^hi cells obtained from either WT or MyD88^−/− TRIF^−/− mice 0 h (black bar) or 24 h after (grey bar) LPS injection. (D) and (E) The average MFI ±SEM (n = 4) of BCL6 in CD11c^hi I-A^int (D) and CD11c^int I-A^hi (E) cells 0 h (black bar) and 24 h after (grey bar) LPS injection. ***p<0.001 (two way ANOVA) was compared within each group.