Figure_6.tif (824.02 kB)
LM11A-31's effect on cholinergic dystrophic neurites in cortex of mid-stage APPL/S mice.
figure
posted on 2014-08-25, 08:51 authored by Danielle A. Simmons, Juliet K. Knowles, Nadia P. Belichenko, Gargi Banerjee, Carly Finkle, Stephen M. Massa, Frank M. LongoRepresentative photomicrographs show ChAT-immunostained dystrophic neurite clusters in the cortex of (A) APPL/S (APP) Veh and (B) APP-31 mice. Scale bar in photomicrograph Aâ=â50 µm. Quantitative analysis showed that LM11A-31 decreases the total area occupied by the clusters (C) by decreasing their number (D) but not the mean area per cluster (E). Statistical significance was determined using a two-tailed Student's t-test (APP Veh, nâ=â10; APP-31, nâ=â9). +p = 0.03 and +++p = 0.001 vs. APP Veh.
History
Usage metrics
Categories
Keywords
basal forebrain cholinergic neuronsbasal forebrain levelsAD mouse modelscholinergic neuritesdystrophic neuritesmolecule p 75NTR ligands1 month LM 11A treatmentcholinergic neurite atrophymodulating p 75NTRSmall Molecule p 75NTR LigandLM 11A Reverses Cholinergic Neurite Dystrophyp 75NTRapplAD mouse modelLM 11Aneurotrophin receptor p 75pathologybasal forebrain cholinergic neuritesp 75NTR ligandDisease Mouse ModelsTg 2576 mice
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC