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Figure S1 - Knock Out of S1P3 Receptor Signaling Attenuates Inflammation and Fibrosis in Bleomycin-Induced Lung Injury Mice Model

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posted on 2014-09-08, 02:58 authored by Ken Murakami, Masataka Kohno, Masatoshi Kadoya, Hidetake Nagahara, Wataru Fujii, Takahiro Seno, Aihiro Yamamoto, Ryo Oda, Hiroyoshi Fujiwara, Toshikazu Kubo, Satoshi Morita, Hiroshi Nakada, Timothy Hla, Yutaka Kawahito

Survival rate after administration of bleomycin. The survival rate after administration of bleomycin. S1P3 knockout (KO) mice (n = 31) and wild-type (WT) mice (n = 34) received a single intratracheal dose of bleomycin (2.15 U/kg). Data from four independent experiments were combined; n = 4–10 mice/group in total. Survival rate of WT mice decreased to 61.8% (21/34) on the eleventh day and survival of S1P3 KO mice to 87.1% (27/31). The survival rate of S1P3 KO mice after administration of bleomycin was significantly higher than that of WT mice (p = 0.039; the data were analyzed by log-rank test).

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