Ketoconazole administration does not alter hypermetabolism or catabolism.
Data are presented as mean ± SEM. A, Resting energy expenditure was significantly higher in control and ketoconazole-treated patients than in non-burned volunteers. There were no significant differences between control and ketoconazole-treated patients. B, Changes in net protein balance induced by burn injury, or more specifically changes in muscle protein synthesis and breakdown, were measured by stable isotope studies using d5-phenyalanine infusion. Black bars indicate week one post burn and white bars week three post burn. There were no significant differences between groups. Both groups were catabolic during the study period. C, There was severe whole-body catabolism post burn. There were no significant differences between groups.