Public Library of Science
Browse
Figure_2.tif (1.83 MB)

Inhibition of parasite growth by BMAP-27 and BMAP-18 peptides.

Download (0 kB)
figure
posted on 2013-02-21, 07:09 authored by Lee R. Haines, Jamie M. Thomas, Angela M. Jackson, Brett A. Eyford, Morteza Razavi, Cristalle N. Watson, Brent Gowen, Robert E. W. Hancock, Terry W. Pearson

MIC assays were performed on trypanosomes and Leishmania using alamarBlue as described in the Materials and Methods. Panel A: Comparison of full length and truncated host defense peptides. T. b. brucei 427.01 BSF (black lines), PCF (gray lines) and Sodalis glossinidius (green lines) were tested for sensitivity to BMAP-27 (solid lines) and BMAP-18 (dashed lines). Percent inhibition is shown as a function of peptide concentration. Panel B: Growth inhibition of a variety of kinetoplastid parasites by BMAP-18. T. b. brucei 427.01 PCF (black line), T. b. brucei TSW196 PCF (magenta line), T. b. rhodesiense ViTat 1.1 PCF (solid green line), T. b. gambiense U2 PCF (red line), T. congolense IL3000 PCF (orange line), T. danilewskyi TrCa (dashed green line), L. donovani LD3 (dashed blue line). The results shown are representative of more than 10 individual experiments (Panel A) or 4 individual experiments (Panel B) performed over a one year period.

History

Usage metrics

    PLOS Neglected Tropical Diseases

    Licence

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC