Inhibition of Wnt5a-induced expression of cytokines and COX-2 in macrophages by BGC-803 derived SFRP5.

(A–H) Real-time PCR and ELISA showed that conditioned medium from SFRP5-transfected BGC-803 suppressed Wnt5a-induced IL-1β, IL-6, TNF-α and COX-2/PGE2 expression in macrophages. *P<0.01. Cont, control; ContV, control vector; WntV, Wnt5a vector; BGC, BGC-803; SFV, SFRP5 vector; ContV, control vector. Data are expressed as mean±SD, n = 3.