Figure_7.tif (225.67 kB)
Inhibition of Wnt5a-induced expression of cytokines and COX-2 in macrophages by BGC-803 derived SFRP5.
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posted on 2014-01-08, 03:00 authored by Chenghai Zhao, Xianmin Bu, Wei Wang, Tingxian Ma, Haiying Ma(A–H) Real-time PCR and ELISA showed that conditioned medium from SFRP5-transfected BGC-803 suppressed Wnt5a-induced IL-1β, IL-6, TNF-α and COX-2/PGE2 expression in macrophages. *P<0.01. Cont, control; ContV, control vector; WntV, Wnt5a vector; BGC, BGC-803; SFV, SFRP5 vector; ContV, control vector. Data are expressed as mean±SD, n = 3.
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Anatomy and physiologyImmune physiologyImmune cellsimmunologyMolecular cell biologyCellular typesEpithelial cellsSignal transductionSignaling cascadesWnt signaling cascadeClinical immunologyGastroenterology and hepatologyGastrointestinal cancersGastrointestinal infectionsStomach and duodenumoncologywnt5a-inducedcytokinescox-2macrophagesbgc-803derived
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