Inhibition of MEK and PI3K alone or in combination alters the transcriptome of the lung during TGFα-induced pulmonary fibrosis.
Heatmap depicting expression levels of total lung genes with at least a two-fold change from CCSP/− control mice on Dox for 8 wks. Differentially expressed genes (up- or down-regulated) by ≥ two-fold in the fibrosis, ARRY, PX-866, ARRY/PX-866 in combination treatment groups are shown. Expression levels of these genes were either maintained or enriched in the combination group as compared to both single inhibitors. Several known fibrotic genes that are significantly down regulated in combined therapy are highlighted using their gene symbols.