Inhibition of MEK and PI3K alone or in combination alters collagen accumulation and pleural thickening during TGFα-induced pulmonary fibrosis.

(A) Representative photomicrographs of lung tissues stained with Masson Trichrome for each treatment group. Upper panel: area of airways, vessels, and parenchyma. Lower panel: pleural regions. Scale bar, 80 µm. (B) Pleural thickness of lung tissues stained with Masson Trichrome for treatment groups. (D) Inhibition of MEK and PI3K alone or in combination alters lung compliance during TGFα-induced pulmonary fibrosis. Data are means ± SEM, and statistical significance between groups was measured using one-way ANNOVA (n = 8–12/group).