Figure_2.tif (1.1 MB)
Influence of sesquiterpene lactones on cell cycle distribution.
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posted on 2013-06-14, 00:34 authored by Birgit Lohberger, Beate Rinner, Nicole Stuendl, Heike Kaltenegger, Bibiane Steinecker-Frohnwieser, Eva Bernhart, Ehsan Bonyadi Rad, Annelie Martina Weinberg, Andreas Leithner, Rudolf Bauer, Nadine KretschmerA) Untreated TE-671 cells were measured as control. B) Treatment of TE-671 cells with the IC50 of costunolide led to a very small change in the distribution, whereas, C) the IC50 of dehydrocostus lactone caused a significant decrease in the number of cells in G1 phase after 48 h which was accompanied by an increase of the number of S and G2/M phase cells. Values are expressed as percentage of the cell population in the G1, S, and G2/M phase of cell cycle. Graphical representations of the cell cycle distribution of D) TE-671, E) SW-872, and F) SW-982 cells.
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Biochemistrydrug discoverybiotechnologyMolecular cell biologyCell deathcell divisionCell growthcytometryPlant sciencemedicinal chemistryDrugs and devicesDrug research and developmentpharmacokineticsoncologyBasic cancer researchmetastasisCancer treatmentChemotherapy and drug treatmentComplementary and alternative medicineCancers and neoplasmsBone and soft tissue sarcomasOncology agentssesquiterpenelactones
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