Influence of sesquiterpene lactones on cell cycle distribution.

A) Untreated TE-671 cells were measured as control. B) Treatment of TE-671 cells with the IC50 of costunolide led to a very small change in the distribution, whereas, C) the IC50 of dehydrocostus lactone caused a significant decrease in the number of cells in G1 phase after 48 h which was accompanied by an increase of the number of S and G2/M phase cells. Values are expressed as percentage of the cell population in the G1, S, and G2/M phase of cell cycle. Graphical representations of the cell cycle distribution of D) TE-671, E) SW-872, and F) SW-982 cells.