Increased porosity of BK<sup>−/−</sup> vertebral trabecular meshwork.

<p>(A, B) Representative 3D reconstructions of the 4<sup>th</sup> lumbar vertebra obtained by high-resolution µCT (A), and corresponding statistics of relative bone mineral density (B) from juvenile WT and BK<sup>−/−</sup> mice (n = 4). (C–F) Representative reconstructions of a cubic region of interest (0.5×0.5×0.5 mm<sup>3</sup>) within the trabecular meshwork of the 4<sup>th</sup> lumbar vertebra (C), and corresponding statistics of bone volume (BV)/tissue volume (TV)-ratio (D), number of nodes (E), trabecles (F) and trabecular thickness (G), evaluated in three cubic regions of interest (0.5×0.5×0.5 mm<sup>3</sup>). Bars: 1 mm (A), 500 µm (C); all data are means±SD; *<i>P</i><0.05; **<i>P</i><0.01.</p>