Implication of prostanoids and K⁺ channels in response to Br-OA.

Concentration-response curves for solvent and Br-OA in intact mesenteric arteries (A) and aortic rings (B) isolated from Wistar rats pre-contracted with PE (5 μM). Curves in intact arteries incubated in the presence of INDO (10 μM) and Gli (5 mM) or 4-AP (1 mM) and combination of the three inhibitors prior to the addition of the drug. Values shown are means ± SEM (n = 7). * p ˂ 0.001 vs control, # vs Br-OA.