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Histograms of absolute z-scores for bipolar disorder (BD, top panels) and schizophrenia (SCZ, bottom panels) for z-scores ≥3.

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posted on 2013-04-25, 00:29 authored by Ole A. Andreassen, Wesley K. Thompson, Andrew J. Schork, Stephan Ripke, Morten Mattingsdal, John R. Kelsoe, Kenneth S. Kendler, Michael C. O'Donovan, Dan Rujescu, Thomas Werge, Pamela Sklar, J. Cooper Roddey, Chi-Hua Chen, Linda McEvoy, Rahul S. Desikan, Srdjan Djurovic, Anders M. Dale

Left panels are actual data, whereas right panels are hypothetical realizations from a doubling of effective sample size, generated from mixture model fits of f(z) = π0f0(z)+(1−π0)f1(z) (see Text S1). Black lines are null sub-densities π0f0(z) and red lines are the full mixture densities f(z). The local false discovery rate is the ratio fdr = π0f0(z)/f(z). Vertical black bars in each plot indicate the cut-points where local fdr≤0.05.

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