Histograms of absolute z-scores for bipolar disorder (BD, top panels) and schizophrenia (SCZ, bottom panels) for z-scores ≥3.

<p>Left panels are actual data, whereas right panels are hypothetical realizations from a doubling of effective sample size, generated from mixture model fits of f(z) = π<sub>0</sub>f<sub>0</sub>(z)+(1−π<sub>0</sub>)f<sub>1</sub>(z) (see <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003455#pgen.1003455.s009" target="_blank">Text S1</a>). Black lines are null sub-densities π<sub>0</sub>f<sub>0</sub>(z) and red lines are the full mixture densities f(z). The local false discovery rate is the ratio fdr = π<sub>0</sub>f<sub>0</sub>(z)/f(z). Vertical black bars in each plot indicate the cut-points where local fdr≤0.05.</p>