Histograms of absolute z-scores for bipolar disorder (BD, top panels) and schizophrenia (SCZ, bottom panels) for z-scores ≥3.

Left panels are actual data, whereas right panels are hypothetical realizations from a doubling of effective sample size, generated from mixture model fits of f(z) = π0f0(z)+(1−π0)f1(z) (see Text S1). Black lines are null sub-densities π0f0(z) and red lines are the full mixture densities f(z). The local false discovery rate is the ratio fdr = π0f0(z)/f(z). Vertical black bars in each plot indicate the cut-points where local fdr≤0.05.