Fig_1.tif (2.75 MB)
H&E-stained paraffin-embedded rat bladder sections.
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posted on 2015-06-10, 03:22 authored by Xiaoxiao Jiang, Yaping Chen, Haitao Zhu, Bo Wang, Ping Qu, Renfu Chen, Xiaoqing SunIn PBOO rats, significant detrusor muscle hypertrophy, alongside a progressive increase in fibrosis (dyed pale pink, blue arrow) and loss of normal muscle tissue (dyed purple or red, black arrow)architecture was observable at 4 and 8 weeks of PBOO. Fibrosis was inhibited in the STS group at (a) week 4 in Sham group, (b) week 4 after PBOO, (c) week 4 after PBOO+STS treatment, (d) week 8 after Sham group, (e) week 8 after PBOO, and(f) week 8 after PBOO+STS treatment. The PBOO and STS groups show detrusor hypertrophy and collagen deposition. Original magnifications, ×40.
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sodium tanshinone IIA sulfonaterat PBOO modeltgfsham operation groupbladder fibrosiscollagen III expressionphosphorylated Smad 2PBOO ratsintraperitoneal vehicle injectiontranscriptase polymerase chain reactionameliorate bladder fibrosisPBOO operationsma8 weeks post PBOOBladder Outlet ObstructionPartial Bladder Outlet ObstructionSTS treatment groupSodium Tanshinone IIA Sulfonate Ameliorates Bladder FibrosisSTS ameliorates bladder fibrosispathway activation
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