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HBE is required for activation of Nodal in the early mouse embryo.

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posted on 2014-06-24, 03:21 authored by Costis Papanayotou, Ataaillah Benhaddou, Anne Camus, Aitana Perea-Gomez, Alice Jouneau, Valérie Mezger, Francina Langa, Sascha Ott, Délara Sabéran-Djoneidi, Jérôme Collignon

Detection of mCherry (A, B, C, and D) and YFP (A′, B′, C′, and D′) in E4.5 (A–B″) or E6.5 (C–D″) aggregation chimeras generated from NodalcondHBE-YFP (A–A″ and C–C″) or NodalΔHBE-YFP (B–B″ and D–D″) ES cells and WT embryos. Images are single confocal sections. Cortical actin in blue. n is the number of representative embryos on the total number of embryos analyzed. Scale bar, 25 µm for E4.5 embryos and 50 µm for E6.5 embryos.

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