Gentiolactone suppresses transcriptional activity of NF-κB.
RAW264.7 cells were transfected with reporter plasmids and cultured with LPS (1 µg/mL) and gentiolactone (500 µM). At 12 hours after LPS stimulation, luciferase activity was measured. Plotted values represent the mean value ± SD from five independent cultures. Helenalin was used as a positive control.