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Genomic context of cis-regulated allele-specific methylation events.

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posted on 2014-06-09, 02:58 authored by John N. Hutchinson, Towfique Raj, Jes Fagerness, Eli Stahl, Fernando T. Viloria, Alexander Gimelbrant, Johanna Seddon, Mark Daly, Andrew Chess, Robert Plenge

Illustrations showing genomic context and individual CpG methylation levels at three separate MPRs (rs10491434 (left), rs6569648 (middle) and rs943049 (right)). The chromosomal location of each amplicon is demonstrated with an ideogram. and the RefSeq genes (orange) surrounding the amplicon (red line) shown below. A section (grey box) contracts to the amplicon region itself to show the relative positions of the SNPs (black lines) and CpGs (blue lines) within the amplicons themselves (red bars); methylation levels of the alternate (grey circles) and reference (yellow circles) alleles within samples heterozygous for the SNP are graphed below each CpG. Asterixes (*) mark the CpGs illustrated within Figure 3.

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