Figure_1.tif (768.45 kB)
Generation of Cthrc1 null mice.
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posted on 2013-02-19, 22:04 authored by J. Patrizia Stohn, Nicole G. Perreault, Qiaozeng Wang, Lucy Liaw, Volkhard Lindner(A) Cthrc1 gene targeting schematic showing replacement of exons 2–4 with a PGK-neo cassette. (B) Embryonic stem cell targeting with Southern blot analysis of genomic DNA from ES cell clones shows a targeted clone. (C) RT-PCR shows lack of Cthrc1 transcripts in RNA preparations of skull bone and whole brain of adult Cthrc1 mutants.
