Generalized partial lymphocyte activation is dependent on an IFN-I response.

Splenocytes from IFN-IR−/−, IFN-IIR−/−, IFN-I&IIR−/− and wild-type 129 mice were analysed for CD69 expression on CD3+ cells 24h following in vivo immunization. Dot plots shows fluorescence profiles from mock, live A/PR8 infected and γ-A/PR8 immunized mice.