Figure_3.tif (229.75 kB)
Frequency distributions of VSAs in the parasite population at endemic equilibrium.
figure
posted on 2010-03-22, 02:15 authored by Sander P. van Noort, Marta C. Nunes, Gareth D. Weedall, Lars Hviid, M. Gabriela M. GomesOpposing selection pressures favour VSA blocks at each end of the dominance hierarchy (solid red line), suggesting a mechanism behind the two clusters displayed in Fig. 3 of [35]. Superinfection selects for high-dominance VSAs (compare solid red line and dotted blue line). When parasites contain multiple VSA blocks, acquired immunity selects for low-dominance variants (compare solid red line and dotted green line). Without superinfection and only a single VSA block per parasite, there is no frequency difference between the different VSA blocks (dotted yellow line).