FKBP12 causes an increase in Ca2+-wave frequency.

(A) Linescan images collected from permeabilised cardiac myocytes under control conditions (top), and in the presence of 3 µM FKBP12 (below). (B) Mean fluorescence records from the linescans shown in panel A. (C) illustrates the mean change in frequency caused by 3 µM FKBP12 (SEM; n = 14; ***p≤0.001) and (D) shows the effect of 3 µM FKBP12 on wave amplitude (SEM; n = 14; *p = 0.028).