FABP4 deficiency is protective against OIR.
(A) Representative FITC-BS1-stained retina flat-mounts from P12 and P17 WT and FABP4−/− mice exposed to hyperoxia. The vaso-obliterated areas are marked in red and the neovascular areas are marked in white. (B) Quantification of the avascular areas shows increased central vaso-obliteration in FABP4−/− retina at P12, which is decreased at P17 (mean ± SEM, n = 7–12 for P12 and n = 15–20 for P17), indicating improved physiological revascularization of avascular areas as indicated by increased slope value (m). (C) Quantification of neovascular area demonstrated a robust inhibition of pathological neovascularization at P17 (mean ± SEM, n = 15–20).