Expression of CXC chemokine receptor 4 (CXCR4) and von Willebrand Factor (vWF) in c-kit+ cells.

Representative optical sections obtained by confocal microscopy demonstrating the co-expression of CXCR4, vWF and c-kit in the pulmonary artery wall of a naïve animal and in pulmonary vascular lesion cells of animals with SU541/chronic hypoxia (SuHx) induced severe PAH. The inserts show the area outlined by a box in more detail. Arrows indicate triple positive cells in the inserts. Nuclear counterstaining: 4’-6-diamidino-2-phenylindole (DAPI). Magnification: 400×. Scale bar: 20 µm.