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Expression of CXC chemokine receptor 4 (CXCR4) and α-smooth muscle actin (α-SMA) in c-kit+ cells.

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posted on 2014-02-24, 03:32 authored by Daniela Farkas, Donatas Kraskauskas, Jennifer I. Drake, Aysar A. Alhussaini, Vita Kraskauskiene, Harm J. Bogaard, Carlyne D. Cool, Norbert F. Voelkel, Laszlo Farkas

Representative optical sections obtained by confocal microscopy demonstrating the co-expression of CXCR4, α-SMA and c-kit in the pulmonary artery of a naïve animal and in pulmonary vascular lesion cells of animals with SU5416/chronic hypoxia (SuHx) induced severe PAH. The inserts show the area outlined by a box in more detail. Arrows indicate triple positive cells in the inserts. Nuclear counterstaining: 4′-6-diamidino-2-phenylindole (DAPI). Magnification: 400×. Scale bar: 20 µm.

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