Exon 1A deletion: Gnas expression and body temperature.
(a) Representation of Gnas expression when the Exon1A-DMR (Ex1A-DMR) is methylated on the maternal (M) allele in +/+ and +/Ex1a or deleted on the paternal (P) allele in +/Ex1a mice. (b) Expression levels, by q-PCR measurements, in BAT tissue of Gnas (left panel) and Ucp1 (right panel) mRNA in +/+ versus mutant +/Ex1a mice. (c) Grand-averages and shadowed ± s.e.m. of body temperature over a 24-hour period for +/+ and +/Ex1a mice. Statistics are reported as following: t-test; ** = P<0.01.